DeDeaux has merged art with new technologies for decades to broaden art and audience engagement.  Early works from the 1970s such as CB Radio Booths were works of mobility that travelled the communication systems and streets of underserved communities. Mid-career works were large-scale installations and pioneering immersive, synchronized media environments including Soul Shadows, Women Eating, and The Face of God that premiered at the 1996 Olympics. Latter works, including Project Mutants, The Goddess Fortuna and The MotherShip Series, are inspired by environmental challenges.

Works by DeDeaux have been exhibited nationwide including Whitney Museum of American Art, Armand Hammer Museum, Aldrich Museum of Contemporary Art of Connecticut, The Contemporary / Baltimore, Canadian Film Society of Toronto, and Ballroom Marfa, Marfa TX. Recent exhibitions include her acclaimed Prospect.2 20,000 square foot multimedia installation The Goddess Fortuna and Her Dunces, and the touring MotherShip Series that adapts the theory that mankind has 100 years left – not to save Earth but to leave. Current exhibitions include a solo exhibition I’ve Seen the Future and It Was Yesterday at Arthur Roger Gallery / New Orleans, her exhibition at MASSMoCA  Thumbs Up for the MotherShip, and her participation in the international exhibition Alrededoreson on Chile’s Island of Chiloe in 2018.

DeDeaux is a 1997 Rome Prize recipient as Knight Foundation Visiting Southern Artist at the American Academy in Rome and selected among the eight most important southern U.S. artists by the 1996 Olympics. She is a 2013 Robert Rauschenberg Foundation Artist in Residence, the 2014 Prospect New Orleans Triennial Alumni of the Year, and the 2015 Artist in Residence at Tulane University’s Center for Bioenvironmental Research.

DeDeaux’s work is the in-depth subject of the concluding chapter of Discipline and Photograph, a book by art theorist James Huginin of Chicago Art Institute and, Five Video Artists by Larry Qualls, Associate Editor for Performing Arts Journal, MIT Press. Her work has been reviewed in numerous publications including New York Times, Art in America, USA Today and ArtForum, and the focus of televised features including CBS Sunday Morning and Canada Public Broadcasting’s series The Future.

DeDeaux is also a writer, publisher and founding editor of Arts Quarterly. She is among the eight founders of the Contemporary Arts Center in New Orleans and served on its Board throughout its formative years. She produced and hosted Louisiana’s first radio program on the arts, Art Now, for National Public Radio affiliate WWNO. As an educator DeDeaux established and directed a comprehensive arts program for a 6,000 inmate facility in Orleans Parish, Louisiana and has been Visiting Artist at a number of institutions including Maryland Institute College of Art, and the Texas A&M Visualization Laboratory within the College of Architecture.

DeDeaux is the winner of the 1976 Demolition Derby in the Louisiana Superdome as the only female contestant in a field of 35 drivers.